pk

Calculate PK parameters

Calculate volume of distribution (Vd), elimination half-life (t½), oral bioavailability (F), and steady-state concentration (Css) from hepatic clearance (CLhep) and plasma unbound fraction (fu,p). Vd is Schmitt 2008 Vss from fu,p, logP and pKa. t½ and Css use plasma CL = CLhep × rb. F accounts for hepatic first-pass only.

post/api/pk/parameters

Request

  • Base URL: https://api.ivive.app
  • URL: https://api.ivive.app/api/pk/parameters
  • Auth: OAuth 2 (password, token URL /api/auth/login)

Request body

clhepnumber required

Hepatic blood clearance CLb (mL/min/kg). From IVIVE calculation or manual input.

fu_pnumber required

Unbound fraction in plasma (0–1). Plasma protein binding correction.

logpnumber required

Octanol:water logP. Drives tissue lipid partitioning in Vss.

pka_acidnumber nullable

Most acidic pKa (proton donor). Omit if the compound has no acidic group.

pka_basenumber nullable

Most basic pKa (conjugate acid of the base). Omit if no basic group.

rbnumber

Blood-to-plasma ratio. CLhep is blood clearance; plasma CL = CLhep × Rb is used for t½ and Css.

dosenumber nullable

Dose (mg/kg). Optional — required for Css calculation.

taunumber nullable

Dosing interval (hours). Optional — required for Css calculation.

species'human' | 'rat' | 'dog'

Species for physiological parameters (Qh used to derive EH).

Response

Successful Response

vdnumber required

Volume of distribution at steady state (L/kg, plasma-referenced). Schmitt 2008 tissue partitioning with Pearce 2017 calibration.

half_lifenumber required

Elimination half-life (hours). t½ = ln2×Vd×1000/(CLp×60), CLp = CLhep×Rb

f_oralnumber required

Oral bioavailability (fraction). F = 1−EH, hepatic first-pass only

cssnumber nullable

Steady-state plasma concentration (µg/L, plasma-referenced), Css = F×Dose/(CLp×τ). Only present when dose and dosing_interval provided

ehnumber required

Hepatic extraction ratio. EH = CLb / Qh

speciesstring required

Species used for calculation

Changes

No recorded changes to this operation across all 1 revision of this API.