model'esm3-open-2024-03' | 'esmfold2-fast-2026-05' | 'esmfold2-2026-05' | 'null' nullable
You may have access to additional, private models as well. These will be visible on the Rate Limits page under the Developer Console
potential_sequence_of_concernboolean
Disclose potential sequences of concern. For approved users, such sequences will not go through additional safety filtering. Reach out if you are interested in using this.
sequencestring nullable
Input sequence to be folded; '|' separates chains. The server names the chains A, B, C in the order they appear.
num_loopsinteger
(ESMFold2) Number of trunk loops for iterative refinement.
num_sampling_stepsinteger
(ESMFold2) Diffusion ODE solver steps. Lower for speed, higher for quality.
lm_dropoutnumber
(ESMFold2) Dropout probability on LM pair embeddings. When > 0, dropout is applied.
lm_mask_pctnumber
(ESMFold2) Fraction of sequence residues randomly masked before the PLM backbone. If not provided, defaults to 0.1 for ESMFOLD2_FAST and 0.0 for ESMFOLD2
msa_max_depthinteger nullable
(ESMFold2) Number of MSA rows randomly subsampled each loop. Set to null to disable (sets msa_subsample_at_inference to False).
msa_column_mask_ratenumber
(ESMFold2) Fraction of MSA columns randomly masked in non-query rows for inference-time diversity.
include_distogramboolean
(ESMFold2) Whether to include distogram predictions in the response.
include_paeboolean
(ESMFold2) Whether to include Predicted Aligned Error (PAE) matrix in the response.
include_pair_chains_iptmboolean
(ESMFold2) Whether to include pair-chain IPTM predictions in the response.
include_embeddingsboolean
(ESMFold2) Whether to include sequence and pair embeddings in the response.