---
title: "Predict human clearance from animal clearance"
method: POST
path: "/api/scaling/allometric"
tags: ["scaling"]
---

# Predict human clearance from animal clearance

`POST /api/scaling/allometric`

## Request

- Base URL: `https://api.ivive.app`
- URL: `https://api.ivive.app/api/scaling/allometric`
- Auth: OAuth 2 (password, token URL `/api/auth/login`)

Scales observed animal in-vivo plasma clearance to human by every method the supplied data supports, each carrying the accuracy it showed on 369 drugs with observed human CL. Everything is plasma CL in mL/min/kg.

Measured on that set, scaling from a single species beat simple allometry across two species, because extrapolating a two-point fit from 0.25 kg and 10 kg out to 70 kg amplifies the error in either point. Methods are returned most accurate first.

## Request body

- ScalingRequest
  - `animals` SpeciesPoint[], required
    - `species` string, required: One of ['dog', 'monkey', 'rat']
    - `cl` number, required: Observed plasma CL, mL/min/kg
    - `fu_p` number, nullable: Unbound fraction in plasma for this species
  - `fu_p_human` number, nullable: Human unbound fraction, needed by the fu-corrected methods

## Response `200`

Successful Response

- ScalingResponse
  - `results` MethodResult[], required: Methods that could be applied, most accurate first
    - `method` string, required
    - `cl_human` number, required: Predicted human plasma CL, mL/min/kg
    - `species_used` string[], required
    - `exponent` number, nullable
    - `accuracy` AccuracySchema: What this method scored on the calibration drugs, so a user can weigh its answer.
      - `aafe` number, required: Geometric mean fold error; 1.0 would be perfect
      - `within_2x` number, required: Percent of drugs predicted within 2-fold
      - `n` integer, required
      - `basis` string, required
    - `source` string, required
    - `note` string, nullable
  - `unavailable` object: Methods that need data not supplied, and what each is missing

## Other responses

- `422`: Validation Error

---

[API](https://skmtc.dev/ivive/apis/ivive-app-api.md) · [All operations](https://skmtc.dev/ivive/apis/ivive-app-api/llms.txt) · [OpenAPI document](https://skmtc.dev/ivive/apis/ivive-app-api/revisions/a67615eaf584?raw)