import {z} from 'zod' export type GetApiSessionsSessionIdBrowserRegionArgs = {session_id: string, chrom: string, start: number, end: number}; export type GetApiSessionsSessionIdBrowserRegionOptions = {baseUrl: string, HTTPBearer?: string | undefined, fetch?: typeof fetch | undefined}; export const browserSnvOut = z.object({chrom: z.string(), pos: z.number().int(), gene: z.string().nullable().optional(), cls: z.string().nullable().optional(), hgvs: z.string().nullable().optional(), ref: z.string().nullable().optional(), alt: z.string().nullable().optional(), bayesdelNoaf: z.number().nullable().optional(), bayesdelNoafPred: z.string().nullable().optional(), spliceaiMax: z.number().nullable().optional(), spliceaiPred: z.string().nullable().optional(), phylop: z.number().nullable().optional(), gerp: z.number().nullable().optional(), alphamissense: z.number().nullable().optional(), sift: z.number().nullable().optional(), metasvm: z.number().nullable().optional(), dann: z.number().nullable().optional(), mpc: z.number().nullable().optional(), af: z.number().nullable().optional(), afGrpmax: z.number().nullable().optional(), popmax: z.string().nullable().optional(), hom: z.number().int().nullable().optional(), loeuf: z.number().nullable().optional(), misZ: z.number().nullable().optional(), pli: z.number().nullable().optional(), clinvarSig: z.string().nullable().optional(), reviewStars: z.number().int().nullable().optional(), clinvarId: z.string().nullable().optional(), criteria: z.string().nullable().optional(), confidence: z.number().nullable().optional(), consequence: z.string().nullable().optional(), impact: z.string().nullable().optional(), hgvsCdna: z.string().nullable().optional(), transcriptId: z.string().nullable().optional(), transcriptRepresentations: z.record(z.string(), z.unknown()).nullable().optional(), exonNumber: z.string().nullable().optional(), domains: z.string().nullable().optional(), pm1Source: z.string().nullable().optional(), vcepApplied: z.boolean().nullable().optional(), vcepPanel: z.string().nullable().optional(), deNovo: z.boolean().nullable().optional(), hiScore: z.number().int().nullable().optional(), tsScore: z.number().int().nullable().optional()}); export const browserSvOut = z.object({chrom: z.string(), start: z.number().int(), end: z.number().int(), svType: z.string().nullable().optional(), cls: z.string().nullable().optional()}); export const browserGeneOut = z.object({chrom: z.string(), symbol: z.string(), start: z.number().int(), end: z.number().int(), strand: z.string().nullable().optional(), exons: z.array(z.number().int()).optional()}); export const browserRegionOut = z.object({chrom: z.string(), start: z.number().int(), end: z.number().int(), axis: z.string(), iscaId: z.string().nullable().optional(), score: z.number().int().nullable().optional()}); export const browserExonPextOut = z.object({chrom: z.string(), gene: z.string(), exonStart: z.number().int(), exonEnd: z.number().int(), maxTissuePext: z.number(), meanPext: z.number(), brainCortexPext: z.number().nullable().optional(), wholeBloodPext: z.number().nullable().optional(), tier: z.string()}); export const browserRegionResponse = z.object({snvs: z.array(browserSnvOut), svs: z.array(browserSvOut), genes: z.array(browserGeneOut), regions: z.array(browserRegionOut), pext: z.array(browserExonPextOut).optional()}); export const validateResponse = async ( schema: { readonly '~standard': { readonly validate: (value: unknown) => ({ readonly value: Output; readonly issues?: undefined } | { readonly issues: ReadonlyArray<{ readonly message: string; readonly path?: ReadonlyArray | undefined }> }) | Promise<{ readonly value: Output; readonly issues?: undefined } | { readonly issues: ReadonlyArray<{ readonly message: string; readonly path?: ReadonlyArray | undefined }> }> } }, value: unknown ): Promise => { const result = await schema['~standard'].validate(value) if (result.issues !== undefined) { const detail = result.issues .map(({ message, path }) => path?.length ? `${path.map((segment) => String(typeof segment === 'object' ? segment.key : segment)).join('.')}: ${message}` : message ) .join('; ') throw new Error(`Response does not match the schema: ${detail}`, { cause: { issues: result.issues } }) } return result.value }; /** * Region read for the genome browser * * GET /sessions/{session_id}/browser/region */ export const getApiSessionsSessionIdBrowserRegion = async (args: GetApiSessionsSessionIdBrowserRegionArgs, options: GetApiSessionsSessionIdBrowserRegionOptions) => { const {baseUrl, fetch: fetchFn = fetch, HTTPBearer} = options ?? {} const query = new URLSearchParams() const headers = new Headers() headers.set('accept', "application/json") if (args.chrom != null) query.append("chrom", String(args.chrom)) if (args.start != null) query.append("start", String(args.start)) if (args.end != null) query.append("end", String(args.end)) if (HTTPBearer !== undefined) headers.set('authorization', `Bearer ${HTTPBearer}`) const url = `${baseUrl.replace(/\/+$/, '')}/sessions/${encodeURIComponent(String(args.session_id))}/browser/region${query.size > 0 ? `?${query}` : ''}` const res = await fetchFn(url, {method: "GET", headers}) if (!res.ok) throw new Error(`Request failed with status ${res.status}`, {cause: {status: res.status, body: await res.text()}}) return validateResponse(browserRegionResponse, await res.json()) };