import {z} from 'zod' export type GetApiPublicV1VariantsReferenceArgs = {chrom: string, start: number, end: number}; export type GetApiPublicV1VariantsReferenceOptions = {baseUrl: string, fetch?: typeof fetch | undefined}; export const publicReferenceCodon = z.object({bases: z.string(), aminoAcid: z.string(), proteinPosition: z.number().int().gte(1), genomicPositions: z.array(z.number().int())}); export const publicReferenceTranscript = z.object({geneSymbol: z.string(), transcriptId: z.string(), proteinId: z.string().nullable(), strand: z.enum(["+", "-"]), exons: z.array(z.array(z.unknown())), cds: z.array(z.array(z.unknown())), codons: z.array(publicReferenceCodon)}); export const publicReferenceResponse = z.object({chrom: z.string(), start: z.number().int().gte(1), end: z.number().int().gte(1), sequence: z.string(), transcript: publicReferenceTranscript.nullable()}); export const validateResponse = async ( schema: { readonly '~standard': { readonly validate: (value: unknown) => ({ readonly value: Output; readonly issues?: undefined } | { readonly issues: ReadonlyArray<{ readonly message: string; readonly path?: ReadonlyArray | undefined }> }) | Promise<{ readonly value: Output; readonly issues?: undefined } | { readonly issues: ReadonlyArray<{ readonly message: string; readonly path?: ReadonlyArray | undefined }> }> } }, value: unknown ): Promise => { const result = await schema['~standard'].validate(value) if (result.issues !== undefined) { const detail = result.issues .map(({ message, path }) => path?.length ? `${path.map((segment) => String(typeof segment === 'object' ? segment.key : segment)).join('.')}: ${message}` : message ) .join('; ') throw new Error(`Response does not match the schema: ${detail}`, { cause: { issues: result.issues } }) } return result.value }; /** * Read a bounded public GRCh38 and MANE reference window * * GET /public/v1/variants/reference */ export const getApiPublicV1VariantsReference = async (args: GetApiPublicV1VariantsReferenceArgs, options: GetApiPublicV1VariantsReferenceOptions) => { const {baseUrl, fetch: fetchFn = fetch} = options ?? {} const query = new URLSearchParams() const headers = new Headers() headers.set('accept', "application/json") if (args.chrom != null) query.append("chrom", String(args.chrom)) if (args.start != null) query.append("start", String(args.start)) if (args.end != null) query.append("end", String(args.end)) const url = `${baseUrl.replace(/\/+$/, '')}/public/v1/variants/reference${query.size > 0 ? `?${query}` : ''}` const res = await fetchFn(url, {method: "GET", headers}) if (!res.ok) throw new Error(`Request failed with status ${res.status}`, {cause: {status: res.status, body: await res.text()}}) return validateResponse(publicReferenceResponse, await res.json()) };