---
title: "Changes to (ESM3, ESMFold2) Folds proteins. Defaults to esmfold2-fast-2026-05 if no model is given"
method: POST
path: "/api/v1/fold"
---

# Changes to (ESM3, ESMFold2) Folds proteins. Defaults to esmfold2-fast-2026-05 if no model is given

`POST /api/v1/fold`

> Every recorded change to this operation, newest first.

## Timeline

Changed in 5 of 7 revisions.

- **2026-10-14** `28a490b11fe1`: 1 info
- **2026-10-03** `2b39e86ec871`: 1 info
- **2026-09-23** `cfa834c15600`: 2 info
- **2026-09-03** `422e4d05cd6d`: 1 info
- **2026-08-26** `b19c9a405304`: 1 breaking

## Changes

- **2026-10-14** `28a490b11fe1`: 1 info
  - added the optional property `sequence` to the response with the `200` status
- **2026-10-03** `2b39e86ec871`: 1 info
  - added the new optional request property `msa/anyOf[#/components/schemas/MSA]/headers`
- **2026-09-23** `cfa834c15600`: 2 info
  - added the new optional `header` request parameter `accept`
  - added the media type `application/vnd.evolutionaryscale.pickle` for the response with the status `200`
- **2026-09-03** `422e4d05cd6d`: 1 info
  - added `subschema #2` to the `msa` request property `anyOf` list
- **2026-08-26** `b19c9a405304`: 1 breaking
  - response property `plddt/anyOf[subschema #1]/items/` list-of-types was widened by adding types `null` to media type `application/json` of response `200`

---

[Operation](https://skmtc.dev/evolutionaryscale/apis/evolutionaryscale-api/docs/api/v1/fold/post.md) - [API](https://skmtc.dev/evolutionaryscale/apis/evolutionaryscale-api.md) - [Page](https://skmtc.dev/evolutionaryscale/apis/evolutionaryscale-api/changes/api/v1/fold/post)